Removing a hair of doubt about BRAF targeting
نویسندگان
چکیده
منابع مشابه
Removing a hair of doubt about BRAF targeting.
In this issue of Blood, Pettirossi et al, including Drs Tiacci and Falini, who led the effort in 2011 defining the BRAF-V600E driving mutation in hairy cell leukemia (HCL),provide extensive laboratory studies showing that inhibitors of BRAF-V600E and/or mitogen-activated protein kinase kinase (MEK) reach their targets and cause HCL cell death
متن کاملDoubt about antidepressant-like effect
Dear Editor: Extensive studies have measured antidepressant-like effects of chemical compounds to discover new drugs for depression treatment or to clarify the molecular mechanisms of depression. Most useful anti-depressants including tricyclics, selective serotonin reuptake inhibitors (SSRIs), noradrenaline reuptake inhibitors (NRIs), serotonin and noradrenaline re-uptake inhibitors (SNRIs), a...
متن کاملLetter: Clarifying doubt about endocrine-related science.
February 18, 2016 Professor Gio Batta Gori Editor, Regulatory Toxicology and Pharmacology, 525B Street, Suite 1900, San Diego, CA 92101-4495, USA. Professor Gori, We are writing on behalf of four associations to express our regret and concern regarding the comments made towards the crop protection industry in the December 2015 commentary by Bergman et al. (2015) entitled “Manufacturing Doubt Ab...
متن کاملDoubts about ‘uncertainty without All the Doubt’
Call the following the storage hypothesis : degreed beliefs are stable attitudes of agents that can be appealed to for predicting and explaining patterns of behavior, judgment, and decision making. [1] the storage hypothesis is that humans have, or it is as if we have, degrees of belief, and our judgment and decision making across a wide range of situations is systematically predicted by them (...
متن کاملTargeting BRAF in multiple myeloma.
In multiple myeloma, it is believed that multiple mutations in different pathways deregulate the intrinsic biology of the plasma cell, resulting in a genetically complex heterogeneous disease. Mutations in the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway have been identified and represent potential targets for therapy in this disease. BRAF, a serine/threonine k...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-12-616318